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Lousy/Extensive Metabolizers, CYP2D6 The development of the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to 7% on the inhabitants has lowered exercise of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These persons are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic antide